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Updated: Jan 15, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
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利用外周CB1对抗性在1,4,5,6-四二胺基胺基替代硫烯类类似物中用于治疗代谢障碍

Pinaki Bhattacharjee1, Szabolcs Dvorácskó1,2,3, Paul Volesky1

  • 1Section on Medicinal Chemistry, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH), 5625 Fishers Lane, Rockville, Maryland 20852, United States.

Journal of medicinal chemistry
|October 11, 2025
PubMed
概括

新的CB1受体对抗剂被开发用于治疗代谢综合征疾病. 化合物11jE2在肥胖小鼠中显示了外周限制和减少食物摄入量和体重.

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