通过E-配置的烯酸中间体,通过rilzabrutinib的替代合成途径

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Updated: Jan 15, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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Daibao Wei1, Jinbo Guo2, Fuqiang Zhu3

  • 1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China.

The Journal of organic chemistry
|October 11, 2025
PubMed
概括

通过使用胺形成,开发出了一种改进的rilzabrutinib合成. 这条新路线使中间产量增加了一倍,避免异构体的分离,并使总产量增加了20倍,从而提高了可持续性.

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