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Updated: Jun 19, 2026

Establishment of a High-throughput Setup for Screening Small Molecules That Modulate c-di-GMP Signaling in Pseudomonas aeruginosa
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Published on: June 30, 2016

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在细菌孤儿受体中选小分子增强蛋白质稳定性的管道

James J Siclari1,2, Denize C Favaro1, Richard H Huang3

  • 1Structural Biology Initiative, CUNY Advanced Science Research Center, New York, New York, USA.

Protein science : a publication of the Protein Society
|October 11, 2025
PubMed
概括

研究人员使用碎片库确定了细菌Per-ARNT-Sim (PAS) 域蛋白的新型小分子配体. 这一发现有助于理解和设计这些信号蛋白用于合成生物学应用.

关键词:
核磁共振光谱法 (NMR) 是一种光谱法.细菌的一元信号传递.带结合的结合方式微流体调制光谱学 微流体调制光谱学热转移测试试验 热转移测试

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Antibiotic Selection00:57

Antibiotic Selection

Overview
Special Staining Techniques01:13

Special Staining Techniques

Specialized staining techniques play a vital role in microbiology by enabling the visualization of specific bacterial structures that remain undetectable with standard microscopy methods. These techniques not only enhance the structural visualization of bacterial cells but also provide critical insights into their pathogenicity and classification. Additionally, they support diagnostic and research endeavors in microbiology by identifying key bacterial features.Capsule Staining for Virulence...
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Bacterial Protein Maturation

Bacterial protein maturation is a tightly regulated process that ensures newly synthesized polypeptides achieve correct functional conformations. This maturation involves a series of modifications, folding events, and quality control steps, often assisted by specialized chaperone proteins.N-Terminal ModificationsThe maturation of bacterial polypeptides begins cotranslationally as the polypeptide exits the ribosome. The first amino acid, N-formylmethionine (fMet), is typically modified at the...
Bacterial Translocation and Protein Secretion01:26

Bacterial Translocation and Protein Secretion

Bacterial protein secretion involves translocation systems to ensure proteins reach their designated locations, including the plasma membrane, periplasm, outer membrane, or the external environment. These translocation systems are vital for bacterial physiology, supporting processes like membrane assembly, enzymatic activity in the periplasm, and interactions with the external environment. The division of labor between Sec and Tat pathways ensures efficiency in handling proteins with diverse...
Inhibitors of Gram-positive Cell Wall Synthesis01:23

Inhibitors of Gram-positive Cell Wall Synthesis

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