在COVID-19大流行之后,急性淋巴细胞白血病的全球负担
Hongxuan Fan1, Yafen Yang2, Yanyan Lu3
1Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, China.
Annals of hematology
|October 11, 2025
概括
儿童急性淋巴细胞白血病 (ALL) 的全球负担显示,COVID-19后的发病率正在下降,但患病率在增加,高中和中等收入地区存在显著差异. 有针对性的战略对于解决这些趋势和改善受影响儿童的结果至关重要.
科学领域:
- 流行病学 流行病学
- 儿科瘤学 儿科瘤学
- 全球健康 全球健康
背景情况:
- 急性淋巴细胞白血病 (ALL) 是全世界最常见的儿童癌症,占儿童癌症诊断的25%.
- 了解ALL负担的时间趋势和差异对于公共卫生干预至关重要.
研究的目的:
- 调查全球ALL的负担,重点关注COVID-19大流行后的时间趋势和差异.
- 利用2021年全球疾病负担 (GBD) 研究的数据进行全面分析.
主要方法:
- 从GBD 2021数据库 (204个国家/地区) 中分析发病率,流行率,死亡率和DALY.
- 计算年龄标准化率 (ASRs) 以实现跨地区和跨时间的可比性.
- 应用联合点回归和EAPC来评估从1990年到2021年的趋势.
主要成果:
- 全球ALL发病率略有上升,而年龄标准化发病率下降 (EAPC = -0.64).
- 年龄标准化流行率增加 (EAPC = 1.4),在2019-2021年期间,高中/中等SDI地区的发病率明显下降.
- 在所有SDI五分位数中,死亡率和DALY趋向下降,但最大的负担仍然在5岁以下的儿童身上,在高中/中SDI地区存在差异.
结论:
- COVID-19大流行影响了全球ALL负担,特别是在高中和中等SDI地区.
- 量身定制的预防策略和改善医疗保健准入对于减轻差异至关重要.
- 需要进一步研究流行病的长期影响,并为高风险人群制定有针对性的干预措施.
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