CDK6

Walter Filgueira de Azevedo1

  • 1Department of Physics, Institute of Exact Sciences, Federal University of Alfenas, Alfenas, MG, Brazil.

概括

研究人员开发了一个神经网络模型来预测循环素依赖性激酶6 (CDK6) 的结合亲和力. 这种机器学习方法为抗癌药物发现提供了卓越的预测性能.

相关概念视频

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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