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药物使用障碍和改变的半球不对称性:系统性审查

Annakarina Mundorf¹, Hicret Atilgan², Lisa Deneke³

¹ISM Institute for Systems Medicine and Department of Human Medicine, MSH Medical School Hamburg, Hamburg, Germany; Department of Neurology, Division of Cognitive Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Clinical psychology review

|October 11, 2025

概括

大脑不对称性,包括结构和功能变化,与物质使用障碍 (SUD) 有关. 这些发现可能会指导个性化成治疗策略.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
成研究研究成研究

背景情况:

药物使用障碍 (SUD) 涉及强迫性寻找药物,尽管负面的结果.
大脑不对称可能会影响SUD患者的认知和情绪失调.
了解这些不对称性对于开发有效的干预措施至关重要.

研究的目的:

系统地审查大脑不对称性和物质使用障碍之间的关系.
综合结构和功能神经成像和行为研究的发现.

主要方法:

在PubMed,Web of Science和PsycInfo的系统文献搜索,直到2025年7月.
包括关于酒,药物滥用和成的原始研究文章与不对称数据.
排除了评论文章,没有匹配组的研究,以及那些具有并发性疾病的研究.

主要成果:

结构成像显示了白色和灰色物质的变化,左半球白质完整性降低,前额/部灰色物质体积减少.
功能神经成像显示SUD患者的右半球补偿激活.
行为侧面化因物质类型,性别和年龄而异.

结论:

显著的结构和功能大脑不对称性与物质使用障碍有关.
这些不对称性,特别是白色和灰色物质以及半球激活模式,是SUD的关键特征.
侧面化的变化表明了个性化治疗方法在成中的潜力.

关键词:

酒精主义酒精主义依赖关系依赖关系双手性是指使用双手.半球不对称性半球不对称性侧面化侧面化侧面化神经成像是一种神经成像.滥用物质滥用物质滥用物质的行为

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