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Updated: Jan 15, 2026

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes
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Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes

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针对EGFR三重突变的PROTACs的合成和降解效应

Xiao-Xiao Xi1, Hong-Yi Zhao1, Minhang Xin1

  • 1Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, PR China.

Bioorganic & medicinal chemistry
|October 11, 2025
PubMed
概括

开发了针对EGFR三重突变的新型PROTAC. 化合物EP9和EP12有效降解了这些突变,为癌症治疗中耐药性提供了新的治疗策略.

关键词:
在EGFR的三重突变中.在PROTAC合成过程中.反扩散活动的反扩散活动.降解效应降解效应的作用非小细胞肺癌的肺癌.

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