对注意力缺陷/多动症和肠道微生物组之间的关联进行系统审查
Marcela França Dias1, Yago Jean de Almeida Nogueira1, Guilherme Soares de Albuquerque1
1Scientific Research Program Molecular Medicine, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
Journal of psychiatric research
|October 11, 2025
概括
肠道微生物组 (GM) 可能会影响注意力缺陷/多动障碍 (ADHD) 症状. 这次审查发现ADHD患者的微生物组成发生了变化,这表明转基因转基因.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 遗传学 遗传学是一种遗传学.
背景情况:
- 注意缺陷/多动障碍 (ADHD) 是一种常见的儿童神经发育障碍.
- 肠道微生物组 (GM) 和通过微生物群-肠道-大脑轴与大脑的连接越来越多地与ADHD相关研究.
- 现有的研究表明,转基因变异与ADHD症状之间存在潜在联系.
研究的目的:
- 系统地审查和评估当前关于人类转基因与ADHD之间的关联的证据.
- 分析微生物的组成,多样性和涉及转基因-ADHD关系的潜在途径.
- 评估GM在ADHD病理生理学中的作用及其治疗策略的潜力.
主要方法:
- 在PubMed,Embase和Scopus数据库中进行了系统的文献搜索.
- 包括14项原始研究,涉及1319名参与者 (67%是男性,年龄在4-18岁之间).
- 研究的重点是评估被诊断患有多动症的个体的转基因特征.
主要成果:
- 在ADHD患者中观察到微生物组成的显著变化,Agathobacter和Ruminococcus gnavus的丰度增加,Faecalibacterium的数量减少.
- 关于ADHD中GM的α和β多样性的研究结果在各个研究中都是不确定的.
- 有证据表明,在ADHD中,转基因,炎症标记物和与神经递质相关的途径之间存在联系.
结论:
- 新出现的数据表明肠道微生物在ADHD病理生理学中的潜在作用.
- 转基因成分的变化可能与ADHD症状有关.
- 肠道微生物组是开发ADHD个性化治疗策略的潜在目标.
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