在低至中等风险的1级高血压的Songling Xuemaikang囊:一个多中心随机的安慰剂受控试验
Yuerong Jiang1, Hua Qu1, Haiyan Guo1
1Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
概括
松林徐梅康囊 (SXC) 有效降低1级高血压患者的血压,心血管风险低至中等. 这项为期8周的试验显示,与安慰剂相比,24小时的门诊血压显著降低,不增加不良事件.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
- 综合医学是一个整体的医学.
背景情况:
- 林徐梅康囊 (SXC) 是一种传统的中国草药,已显示出降低血压的潜力.
- 然而,它在1级高血压和低至中等心血管风险的患者中的有效性需要进一步研究.
研究的目的:
- 评估Songling Xuemaikang囊 (SXC) 在低至中等心血管风险患者的1级高血压管理中的有效性.
主要方法:
- 进行了一项多中心,随机,双盲,安慰剂控制的临床试验.
- 393名患者随机分配,接受SXC或安慰剂8周.
- 主要结局是24小时门诊血压的变化;次要结局包括白天/夜间血压,办公室血压和高血压控制率.
主要成果:
- 与安慰剂相比,SXC显著降低了24小时的静缩和静缩血压 (SBP/DBP) (p < 0.001).
- 在SXC组中观察到,白天,夜间和办公室SBP/DBP的减少更大 (p ≤0.046).
- 在SXC组中,24小时高血压控制率明显高 (38.04%对24.42%,p = 0.002).
结论:
- 与安慰剂相比,SXC治疗8周的疗法在减少24小时平均SBP/DBP方面表现出更好的疗效.
- SXC耐受性良好,两组之间的不良事件没有显著差异.
- 对于低至中度心血管风险的1级高血压患者来说,SXC是一个潜在的替代治疗选择.
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