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通过AlphaShape-enabled虚拟查发现基于胺的Mcl-1抑制剂

Yiming Nie1, Jintong Du2, Xin Yan3

  • 1Department of Medicinal Chemistry, Shandong Key Laboratory of Druggability Optimization and Evaluation for Lead Compounds, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.

European journal of medicinal chemistry
|October 11, 2025
PubMed
概括

研究人员确定了针对骨髓细胞白血病1 (Mcl-1) 的新型本齐米达化合物,用于胰腺癌治疗. 这些化合物表现出强烈的结合,并诱导癌细胞死亡,验证了一种新的AI查方法.

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