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Updated: Jan 15, 2026

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基于功能组导向战略的新型PPAR激动剂的设计,合成和抗糖尿病评估

Sule Bai1, Yi Zou1, Yanping Li1

  • 1China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin, 300457, China.

European journal of medicinal chemistry
|October 11, 2025
PubMed
概括

新型化合物1d和2d选择性地向过氧体增殖器激活受体玛 (PPARγ) 途径. 这些化合物在2型糖尿病模型中改善葡萄糖和脂质代谢,没有体重增加或液体保留等不良影响.

关键词:
胰岛素耐药性 胰岛素耐药性是一种脂质代谢 脂质代谢 是一种在PPAR调节器.在Ser273酸化中.这就是T2DM.

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