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Updated: Jan 15, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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强大的迷你PROTAC:一种新兴的降解剂类别

Xiao Chen1, Kefan Liao1, Jiawei Yuan1

  • 1Department of Biochemistry, Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen, 518055, China.

European journal of medicinal chemistry
|October 11, 2025
PubMed
概括

迷你PROTAC利用N-end规则途径进行向蛋白质降解,提供一种新的方法来克服向蛋白质分解的嵌合体发展的挑战,并增强药物特性.

关键词:
氨基酸是氨基酸的组成部分.这是 Degron Degron 的意思.没有链接器的免费链接器在 N-end 规则路径中.这就是PROTAC.乌比基因结合酶的使用.这是一个迷你PROTAC.

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