路径将不良童年经历与尼日利亚拉各斯的精神病风险联系起来:一个结构方程建模方法
Abiodun O Adewuya1, Olabisi E Oladipo2, Robin Emsley3
1Department of Behavioural Medicine, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria; Centre for Mental Health Research & Initiative, Lagos, Nigeria.
儿童不良经历 (ACE) 与尼日利亚的精神病有关. 心理和认知因素调解了这种联系,特别是家庭病史和出生并发症.
科学领域:
- 精神病学是一个精神病学.
- 全球心理健康全球心理健康
- 流行病学 流行病学
背景情况:
- 儿童不良经历 (ACE) 是已知的精神病风险因素,但低收入和中等收入国家 (LMICs) 的数据很少.
- 这项研究探讨了尼日利亚的ACE,精神病类似经历 (PLEs) 和精神病,调查调解心理和认知途径.
研究的目的:
- 检查尼日利亚人口中ACE和精神病之间的关联.
- 为了确定ACEs-精神病关系的心理和认知调解者.
- 通过家族病史和围产因素来探索适度.
主要方法:
- 使用了拉各斯州心理健康调查 (N=1953) 的数据,包括病例 (持久性PLE/精神病) 和匹配的对照.
- 采用通用结构方程建模来分析直接关联,调解和调节.
- 在一个较大的代表性样本 (N=11,246) 上使用反向概率权重进行的人口验证.
主要成果:
- 与PLEs和精神病诊断显著相关的ACE (p<0.05).
- 常见的精神障碍 (CMD) 和恢复力显著介导了ACEs-精神病联系 (占总影响的21%和23%).
- 认知功能调解了18%的关联;家族病史和产科并发症调节了途径.
结论:
- 通过心理和认知途径,ACE与尼日利亚的精神病有显著的关联.
- 家庭和围产期的脆弱性放大了ACE对精神病风险的影响.
- 在LMICs的干预应侧重于创伤知情护理,弹性建设和社区支持.
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