腰椎间盘的患者中的含量:系统性审查和元分析
Ayman M Zaroug1, Mustafa Alkhawam2, Monther M Hroub3
1Omdurman Islamic University, Faculty of Medicine, Khartoum, Sudan.
概括
与健康个体相比,腰椎间盘 (LDH) 患者的血清水平较低. 可能会重新分发到退化的磁盘组织中,可能是由于矩阵金属蛋白酶 (MMP) 活性增加.
科学领域:
- 生物化学 生物化学
- 整形外科 整形外科 整形外科
- 微量元素研究 微量元素研究
背景情况:
- 是影响矩阵金属蛋白酶 (MMPs) 的关键微量元素,这些酶是腰椎椎间盘退化的中心.
- 腰椎间盘 (LDH) 是腰部疼痛的一个重要原因,但在其病变发生中的作用仍然未被探索.
研究的目的:
- 系统地审查和对LDH患者血清和椎间盘 (IVD) 水平的现有研究进行元分析.
- 调查含量与LDH发生之间的潜在关联.
主要方法:
- 在主要数据库 (Scopus,科学网,PubMed,Embase,Cochrane图书馆) 进行了全面的文献搜索.
- 包括测量LDH患者血清或IVD度的研究.
- 进行了三次元分析:单臂血清和IVD,双臂对比LDH患者和健康对照之间的血清.
主要成果:
- 包括11项研究,评估血清 (6项研究) 或IVD (5项研究) 中的水平.
- 与健康对照组相比,患有LDH的患者的血清度显著降低 (SMD = -1.02;P < 0.0001).
- 在LDH患者中,聚合分析表明血清的平均水平较低 (98.7μg/dL),IVD的平均水平较高 (30.27 mg/kg).
结论:
- 这一综述表明,LDH患者血清含量下降的趋势.
- 在一些研究中观察到椎间盘 (IVD) 中的度升高.
- 提出了从血清到退化的IVD组织中再分配的假设,可能是由MMP上调驱动的,这需要进一步调查.
相关概念视频
Herniated Intervertebral Disc l: Introduction
Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
Degenerative Disc Disease I: Introduction
Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Degenerative Disc Disease ll: Pathophysiology
The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...

