有氧运动通过提高维生素D受体的调节来减轻细胞内脂质的积累
Ke Wang1, Jing-Hua Zhang2, Xiao-Ning Cui1
1School of Exercise and Health, Shanghai University of Sport, Shanghai, 200438, China.
Molecular and cellular endocrinology
|October 11, 2025
概括
有氧运动可以减少细胞内脂质的积累,这是胰岛素抵抗的一个因素. 这种改善与维生素D受体 (VDR) 信号传递和增强的脂肪酸氧化有关,特别是在骨肌肉中.
科学领域:
- 运动生理学 运动生理学
- 营养生物化学 营养生物化学
- 代谢健康 代谢健康
背景情况:
- 维生素D缺乏是一个全球性健康问题,与细胞内脂质 (IMCL) 积累和胰岛素抵抗有关.
- 众所周知,有氧运动可以改善脂质代谢,胰岛素敏感性和维生素D水平,但其调节IMCL的确切机制尚不清楚.
研究的目的:
- 研究维生素D受体 (VDR) 在调解有氧运动对细胞内脂质 (IMCL) 代谢和骨肌肉中的脂肪酸氧化的作用中的作用.
主要方法:
- 使用C57BL/6J小鼠模型,包括维生素D缺乏 (VDD) 和骨肌特异性VDR-knockout (mVDR-/-) 的小鼠,接受了为期12周的有氧运动计划.
- 分析了与脂质代谢 (合成和分解) 和脂肪酸氧化相关的基因和蛋白质表达 (例如,VDR,ATGL,HSL,DGAT1,FATP1,SIRT1,PGC1α).
主要成果:
- 在小鼠中,维生素D缺乏 (VDD) 导致VDR表达减少,脂解和脂肪酸氧化减少,脂质合成增加.
- 在VDD小鼠 (VDDE) 中,有氧运动显著增加了VDR,脂解和脂肪酸氧化因子,同时降低了脂质合成因子.
- 骨肌特异性VDR淘汰 (mVDR-/-) 鼠标显示脂质代谢和脂肪酸氧化受损,而运动在这些鼠标中没有改善 (emVDR-/-).
结论:
- 有氧运动通过提高维生素D受体 (VDR) 的调节来减轻IMCL积累.
- 这一过程涉及恢复SIRT1/PGC1α信号传输,该信号传递促进了骨肌肉中改善的脂质代谢.
- VDR在调解有氧运动对骨肌肉脂质代谢的有益影响方面发挥着至关重要的作用.
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