脊髓炎促进尾部脊髓炎中三级淋巴体器官的形成
Hiba Hasan1, Christiane Pleuger1, Dingding Ai1
1Institute of Anatomy and Cell Biology, Justus Liebig University of Giessen, Giessen, Germany; Hessian Centre of Reproductive Medicine, Justus Liebig University of Giessen, Giessen, Germany.
Mucosal immunology
|October 11, 2025
概括
泌尿病原性大肠杆菌感染会导致尾巴 (cauda epididymidis) 的炎症. 三级淋巴体器官 (TLOs) 形成,可能会长期影响男性生育能力.
科学领域:
- 免疫学 免疫学 免疫学
- 生殖生物学 生殖生物学
- 病理学 病理学 病理学
背景情况:
- 尿病原性大肠杆菌 (UPEC) 感染尾巴的流行病导致炎症,,和精子数量减少.
- 现有的抗生素治疗效果有限,患者患病率很高.
- 不孕症后流行性炎背后的机制需要进一步研究,特别是在晚期疾病阶段.
研究的目的:
- 在UPEC感染的晚期后急性阶段,研究尾状尾虫的组织病理学和免疫学变化.
- 阐明三级淋巴体器官 (TLOs) 在流行性炎和男性不孕症的背景下所起的作用.
主要方法:
- 使用了急性细菌性脊髓炎的小鼠模型.
- 组织病理学分析确定了有组织的三级淋巴体器官 (TLOs) 与B和T细胞群和高内皮静脉 (HEV).
- 转录组分析评估了支持TLO形成的微环境;对人类样本进行了TLO存在和CXCL13水平的检查.
主要成果:
- 组织的TLOs,包括分隔的B和T细胞集群和活跃的生殖中心,在小鼠在UPEC感染后28天的cauda epididymidis中形成.
- 转录组数据证实了有利于TLO形成和维护的微环境.
- 与HEV相邻的TLOs也在人类慢性流行性炎症病例中观察到,患者的血清CXCL13水平升高.
结论:
- 在UPEC感染后,第三级淋巴体器官 (TLOs) 在尾巴上形成.
- 这些TLO含有功能活跃的生殖中心.
- 在尾巴流行病菌中存在TLOs可能会导致男性生育能力的长期损害.
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