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中性粒细胞化学吸引剂CXCL5在急性肺损伤中增加了肺屏障的透性

Sarah Berger¹, Cengiz Goekeri¹, Peter Pennitz¹

¹Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases, Respiratory Medicine and Critical Care, Berlin, Germany.

Mucosal immunology

|October 11, 2025

概括

化学物质CXCL5通过破坏膜-上皮屏障而加剧急性肺损伤,独立于中性粒细胞的招募. 向CXCL5可能会减少炎症,并在严重的肺炎中保持肺功能.

科学领域:

肺部医学肺部医学
免疫学免疫学免疫学
细胞生物学细胞生物学

背景情况:

急性肺损伤 (ALI) 是肺炎的严重并发症,其特征是炎症和肺壁垒的破坏.
中性粒细胞的招募是ALI发病的一个关键因素,但其他机制也可能导致屏障功能障碍.

研究的目的:

调查化学基因CXCL5在ALI和肺屏障完整性中的作用.
为了确定CXCL5是否影响中性粒细胞招募独立于膜上皮膜屏障的功能.

主要方法:

在重症肺炎患者中分析CXCL5水平.
使用野生型和Cxcl5缺乏的小鼠进行ALI的体外和体内模型.
人类膜上皮细胞暴露于CXCL5.5.
单细胞转录组学用于分析上皮细胞基因表达.

主要成果:

肺炎和机械通风增加了人类和小鼠的CXCL5水平.
缺乏Cxcl5的小鼠在ALI期间表现出完整的膜上皮屏障,中性粒细胞透率降低.
单细胞转录组学揭示了Cxcl5缺陷小鼠上皮细胞中细胞结基因的表达增加.
暴露于CXCL5损害了人类膜上皮细胞的屏障功能.

结论:

通过增加膜上皮膜屏障的透性,CXCL5有助于ALI,独立于其在中性粒细胞招募中的作用.
准CXCL5可能是一个潜在的治疗策略,以减少炎症和在严重的细菌性肺炎中保持肺障碍功能.

关键词:

急性肺损伤是什么?急性肺损伤是什么?化学因子 (chemokines) 是一种化学物质.皮质细胞是表皮细胞.中性粒细胞中性粒细胞.肺炎是一种肺炎.

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