在喘和过敏中免疫耐受性的环境决定因素
Piia Karisola1, Harri Alenius2
1Human Microbiome Research (HUMI), Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Immunology letters
|October 11, 2025
概括
暴露组,或总环境暴露,显著影响免疫耐受性和过敏的发展,特别是在生命早期. 了解这些联系为过敏预防策略提供了新的途径.
科学领域:
- 环境健康 环境健康
- 免疫学 免疫学 免疫学
- 过敏研究 研究过敏
背景情况:
- 全球过敏疾病的流行率正在上升,与环境和行为转变有关.
- 暴露组概念为了解影响免疫耐受性的累积终身暴露提供了一个框架.
- 早期暴露对塑造免疫反应和过敏易感性至关重要.
研究的目的:
- 审查当前关于曝光体如何调节免疫耐受性的知识.
- 概述准确预防过敏的未来研究方向.
- 综合环境暴露和过敏结果之间的联系.
主要方法:
- 文献综述综合当前的科学知识.
- 对屏障-微生物群-免疫轴的机制性见解的分析.
- 对暴露组知情的过敏预防的翻译研究的评估.
主要成果:
- 早期的暴露,如污染物和饮食变化,可以破坏免疫耐受性,促进过敏.
- 增强生物多样性和均衡营养的环境因素通过调节性T细胞支持耐受性发展.
- 屏障-微生物群-免疫轴是连接环境暴露与过敏疾病的关键途径.
结论:
- 暴露体知情方法对过敏预防有希望,包括生物多样性丰富和微生物组疗法.
- 在测量暴露混合物,确定因果关系和整合数据方面仍然存在挑战.
- 进一步的研究对于精确的预防和解决全球过敏负担至关重要.
相关概念视频
Asthma-I: Introduction
3.4K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.4K
Asthma-II: Pathophysiology and Classification
4.1K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.1K
Asthma: Pathogenesis and Management
1.2K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.2K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
1.7K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.7K
Allergic Reactions
32.0K
Overview
32.0K
Drugs Used in Lower Respiratory Disorders: Overview
1.0K
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
1.0K


