休息状态fMRI信号可以识别抑郁症患者的双极风险特征及其与认知功能关系
Yinghong Huang1, Wenyue Gong2, Moxuan Song1
1Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
Journal of affective disorders
|October 11, 2025
概括
患有重度抑郁症 (MDD) 风险较高的双相情感障碍 (BD) 患者表现出独特的大脑模式和更好的认知功能. 这表明它是一种独特的亚型,需要个性化治疗.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 患有双相情感障碍 (BD) 风险的大型抑郁症 (MDD) 患者可能代表一个独特的亚型.
- 这一MDD+亚组的神经认知和神经功能特征尚未得到充分研究.
研究的目的:
- 研究患有BD风险的MDD患者 (MDD+) 独特的神经认知和神经功能特征.
- 将MDD+与没有BD风险的MDD (MDD-) 和被诊断为BD患者进行比较.
主要方法:
- 使用休息状态fMRI和认知评估.
- 参与者包括139名BD,181名MDD+和138名MDD患者.
- 神经成像分析包括低频波动的幅度 (ALFF) 和功能连接 (FC).
主要成果:
- 与MDD和BD相比,MDD+显示出明显的ALFF和FC模式.
- 在处理速度和认知灵活性方面,MDD+的表现优于MDD和BD.
- 观察到神经成像指数和认知表现之间的相关性,尽管并非所有人都经过了校正.
结论:
- MDD+表现出独特的认知和神经特征,支持一个独特的抑郁亚型.
- 这些发现强调了需要精细的表型化,以便早期识别和个性化治疗情绪障碍.
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