伴随着失眠的情绪障碍的男性加速表观遗传衰老
Zehan Ma1, Suqin Shen2, Meng Hao1
1MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.
Journal of affective disorders
|October 11, 2025
概括
情绪障碍 (MDs) 与加速衰老有关. 男性MD患者的失眠严重程度与表观遗传年龄加速 (AgeAccelGrim) 有显著的相关性,这表明失眠症.
科学领域:
- 老年学是一门学科.
- 精神病学是一个精神病学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 情绪障碍 (MDs) 与过早死亡和加速衰老有关.
- 表观遗传年龄 (EA) 作为生物衰老的生物标志物,之前的研究表明在MD中表观遗传年龄加速 (EAA).
- 在MD中EAA和特定的临床症状之间的联系仍然不清楚.
研究的目的:
- 研究表观遗传衰老加速 (EAA) 与情绪障碍 (MD) 患者的临床症状之间的关联.
- 探索MD患者和健康对照者之间的EAA的潜在差异,以及MD组内的性别差异.
- 为了确定与表观遗传衰老标记相关的特定MD症状.
主要方法:
- 从251名MD患者和181名对照患者的血液样本中分析了全基因组DNA甲基化.
- 用四个表观遗传钟和基于DNA甲基化的端粒长度 (DNAmTL) 来计算EA和EAA.
- 研究了EAA测量和汉密尔顿抑郁量表 (HAMD-17) 症状因子之间的关联,包括按症状严重程度进行子组分析.
主要成果:
- 在MD患者和对照人群之间,没有发现EAA或DNAmTLadjAge的总体显著差异.
- 与女性患者相比,男性MD患者的衰老显著加速.
- 在男性MD患者中,AgeAccelGrim和失眠严重程度之间观察到强烈的相关性,严重的失眠与更高的AgeAccelGrim和高的DNAm GDF15,莱普和TIMP-1有关.
结论:
- 失眠可能在男性情绪障碍患者观察到的加速衰老过程中发挥重要作用.
- 这些发现有助于了解MDs-aging关系,并可能为患者分层和治疗策略提供信息.
- 表观遗传衰老标志物,特别是与失眠有关的标志物,为MD的有针对性的干预提供了潜力.
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