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在心脏外科手术中使用复合凝血因子VIIa (rFVIIa - NovoSeven®) 后发生的血栓栓塞事件的表征:描述性试点研究
Delphine Boden1, Camille Bouchand1, Charlotte Fenat1
1Pharmacy department, Nantes University Hospital, 44000 Nantes, France.
Annales pharmaceutiques francaises
|October 11, 2025
概括
重组激活因子VII (rFVIIa) 在心脏手术中用于大量出血. 较高剂量的rFVIIa与术后血栓栓塞事件有关,需要进一步调查.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 手术科学 手术科学
背景情况:
- 心脏手术存在大量出血的重大风险.
- 重组激活因子VII (rFVIIa) 是一种潜在的治疗严重出血不响应标准疗法.
- 然而,rFVIIa的使用与血栓栓塞的风险有关.
研究的目的:
- 描述rFVIIa在心脏手术期间管理大量出血的利用.
- 在这个患者群体中调查rFVIIa给药后发生的血栓栓塞事件的发生率.
主要方法:
- 从2019年1月到2021年12月进行了一项单心观测研究.
- 包括的患者接受了rFVIIa,用于心脏手术后大规模出血.
- 收集的数据包括患者人口统计,手术细节,出血管理,rFVIIa剂量和术后血栓栓塞事件.
主要成果:
- 包括67名患者;常见的手术是大动脉剖析 (46%) 和门置换 (33%).
- 平均rFVIIa剂量为10±5mg (129±67μg/kg). 这是一个很大的问题.
- 术后血栓栓塞事件发生在33%的患者中,主要发生在上腔静脉 (73%).
结论:
- 这项研究描述了rFVIIa在心脏手术后大量出血的使用情况.
- 在经历了血栓栓塞事件的患者中观察到更高的平均rFVIIa剂量.
- 需要进一步的研究来确定rFVIIa和术后血栓栓塞事件之间的因果关系.
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