在没有风险因素的情况下,炎症和心血管疾病之间的关联
Yingting Zuo1, Shuohua Chen2, Shouling Wu2
1Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|October 11, 2025
概括
较高的中性粒细胞计数与缺乏传统风险因素的健康成年人心血管疾病 (CVD) 风险增加有关. 这一发现强调了中性粒细胞作为看似健康的个体中心血管疾病的潜在生物标志物.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 风险评估通常依赖于传统因素.
- 在没有这些因素的人群中,中性粒细胞数量作为心血管疾病风险标志物的证据有限.
研究的目的:
- 调查中性粒细胞数量与患心血管疾病的风险之间的关联.
- 探索中性粒细胞计数作为健康人群中潜在的生物标志物.
主要方法:
- 分析了Kailuan研究 (2006-2007) 中35,975名参与者的数据.
- 参与者在发生心血管疾病事件 (心肌梗塞,中风) 的中位数是14.98年.
- 中性粒细胞计数被分类为三位数,并使用Cox比例危险模型进行分析.
主要成果:
- 中性粒细胞数量较高的三分位数与心血管疾病风险增加有显著的关联.
- 调整后的第二个和第三个三位数的危险比分分别为1.42和1.34 (趋势P<0.001).
- 在中性粒细胞计数和心血管疾病风险之间观察到J形关联,也注意到hs-CRP.
结论:
- 增加的中性粒细胞计数预测在没有传统动脉样硬化心血管疾病 (ASCVD) 风险因素的人群中增加心血管疾病风险.
- 研究结果表明,中性粒细胞可能作为CVD风险分层的有价值生物标志物.
- 该研究的男性占主导地位的队列可能会限制概括性;在多样化的群体中进行进一步研究是有必要的.
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