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整合全身疗法和转移导向疗法在荷尔蒙敏感的小卵性转移性前列腺癌中

Xiaolei Shi¹, Jarey H Wang², Brian F Chapin³

¹Department of Hematology Oncology, University of Maryland Medical Center, Baltimore, MD, USA.

Prostate cancer and prostatic diseases

|October 11, 2025

概括

转移导向疗法 (MDT) 改善了小转移性激素敏感前列腺癌 (omHSPC) 的结果,特别是与全身治疗相结合时. 需要进一步的研究来优化其在标准护理中的作用.

科学领域:

在瘤学瘤学.
泌尿器科泌尿器科泌尿器科泌尿器科
放射学放射学是一门学科.

背景情况:

荷尔蒙敏感性前列腺癌 (omHSPC) 是一种可治愈的状态,其中转移导向疗法 (MDT) 提高了结果.
将MDT与全身治疗相结合,代表了对OMHSPC管理的有希望的进步.

研究的目的:

审查MDT对同步和超时的潜在试验 omHSPC.
综合单独使用MDT与综合系统治疗的证据.
突出高级成像和基因组学在完善OMHSPC治疗策略中的作用.

主要方法:

在 omHSPC 中对前性试验 (STOMP,ORIOLE,EXTEND,RADIOSA) 和元分析 (X-MET) 的审查.
重点是临床结果,无进展生存期 (PFS) 和生物标志物数据.
评估先进的成像技术,如PSMA-PET用于MDT规划.

主要成果:

在甲时性omHSPC (STOMP, ORIOLE) 中,MDT显著改善PFS,并延迟雄激素剥夺疗法 (ADT).
将MDT与短期ADT相结合显示出改善的结果 (EXTEND,RADIOSA).
先进的成像增强了MDT规划的病变检测;MDT在同步omHSPC中的作用正在调查中.

结论:

在甲时性omHSPC中,MDT提供了临床益处,特别是在全身疗法中.
先进的成像和基因组学是omHSPC患者选择的关键.
较大的随机试验对于确定MDT与ADT+ARPI疗法的作用至关重要.

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