心血管疾病中的细胞外囊泡:信号,生物标志物和治疗方法
Wenxi Chen1,2, Xinyi Zhu1,2, Shuo Yu3
1Department of Cardiology, State Key Laboratory of Transvascular Implantation Devices; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, the Second Affiliated Hospital, Zhejiang University School of Medicine, Transvascular Implantation Devices Research Institute, Hangzhou, 310009, China.
Journal of cardiovascular translational research
|October 11, 2025
概括
细胞外囊泡 (EVs) 在诊断和治疗心血管疾病 (CVDs) 方面表现有前途. 这些天然纳米粒子可以被设计为有针对性的药物输送和改善心血管疾病管理.
科学领域:
- 生物医学工程 生物医学工程
- 心血管研究研究心血管研究
- 纳米医学是一种纳米医学.
背景情况:
- 心血管疾病 (CVD) 是全球主要的死亡原因,推动了对创新的诊断和治疗策略的需求.
- 细胞外囊泡 (EVs),包括外体和微囊泡,是心血管系统中至关重要的细胞间通信器,携带miRNA和调节关键病理过程的蛋白质.
- 由于其可访问性和特定疾病的分子形状,EV提供了非侵入性诊断潜力,并且由于其内源性和向能力,它们是理想的药物输送车辆.
研究的目的:
- 探索细胞外囊泡 (EV) 作为心血管疾病 (CVD) 的诊断工具和治疗药物输送平台的潜力.
- 讨论EV的工程,以提高治疗应用中的特异性,以及阻碍其临床转化的挑战.
- 突出基于EV的干预措施对心肌梗塞,动脉样硬化和心力衰竭等疾病的承诺.
主要方法:
- 关于细胞外囊泡 (EV) 生物学和功能在心血管环境中的当前研究的审查和综合.
- 从EVs的分子特征中得出的诊断潜力的分析.
- 工程电动汽车作为毒品载体的评估,考虑表面修改和货物装载以进行有针对性的交付.
主要成果:
- 电动体调节关键的心血管过程,包括炎症,纤维生成和血管生成.
- 工程电动汽车在心血管疾病模型中表现出治疗应用的增强特异性.
- 仍然存在重大挑战,包括可重现性,长期安全性,清关和可扩展制造等问题.
结论:
- 细胞外囊泡 (EVs) 代表了诊断和治疗心血管疾病 (CVDs) 的前沿.
- 工程电动汽车为开发有针对性的药物输送系统提供了一条途径,在心肌梗塞,动脉样硬化和心力衰竭中具有潜在的应用.
- 克服标准化和安全方面的当前挑战对于基于电动汽车的诊断和心血管疾病的再生疗法的临床转化至关重要.
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