在末期病患者中,脑脊液循环和神经血管脱的功能障碍与轻度认知障碍
Zhaoyao Luo1, Lurui Bo1,2, Xinyi Zhu1
1Department of Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China.
GeroScience
|October 11, 2025
概括
脑脊液 (CSF) 循环问题和神经血管合 (NVC) 损伤在末期病 (ESRD) 患者中与轻度认知障碍 (MCI) 有关. 通过影响NVC,CSF功能障碍可能会恶化认知能力下降.
科学领域:
- 神经科学是一个神经科学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 放射学 放射学是一门学科.
背景情况:
- 末期病 (ESRD) 与轻度认知障碍 (MCI) 相关,影响患者的生活质量.
- 脑脊液 (CSF) 循环功能障碍和神经血管合 (NVC) 障碍与认知障碍有关,但它们在ESRD-MCI中的关系尚不清楚.
研究的目的:
- 在患有MCI的ESRD患者中调查CSF循环功能障碍和NVC中断之间的关联.
- 探索NVC在CSF循环和ESRD认知衰退之间的关系中的调解作用.
主要方法:
- 将68名患有MCI的ESRD患者与65名健康对照人进行了比较.
- 评估了使用状交叉体体体积 (CPV),DTI-ALPS指数和PVSVF的CSF循环.
- 使用脑血流 (CBF) 与静止状态fMRI指标 (ALFF,fALFF,ReHo) 之间的合指标评估NVC. 用神经心理测试测量认知表现.
主要成果:
- 与HC相比,ESRD患者的CPV和PVSVF增加,DTI-ALPS指数下降.
- 在ESRD患者中观察到显著减少的全球和区域NVC指标.
- 区域NVC指标与CPV负相关,CBF-ReHo合介导了CPV升高和认知衰退之间的联系.
结论:
- 在ESRD-MCI中,CSF循环功能障碍和受损的NVC相互关联.
- 脑脊液循环的破坏可能会通过损害NVC,导致认知能力下降.
- 脑脊液循环和NVC是早期诊断和干预ESRD相关认知障碍的潜在目标.
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