在神经病性角膜疼痛中维生素异常
Bing Jie Chow1, Mingyi Yu2, Chang Liu2
1Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Eye and vision (London, England)
|October 11, 2025
概括
用B3,B12和D补充维生素对治疗神经病性角膜疼痛 (NCP) 有希望. 需要进一步的研究,以建立最佳的协议,以治疗这种衰弱的条件.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 营养科学 营养科学
背景情况:
- 神经性角膜疼痛 (NCP) 是由于神经功能障碍而引起的自发角膜疼痛的特征,通常没有明显的眼睛表面异常.
- 像灼热疼痛,光恐惧和刺激这样的症状是深刻的,难以管理的,基于有限的证据的临床建议.
- 维生素缺乏与NCP有关,这表明维生素补充剂的潜在治疗作用.
研究的目的:
- 审查维生素B3,B12和D对神经病性角膜疼痛 (NCP) 的治疗潜力.
- 探索这些维生素可以缓解NCP症状的机制.
- 确定NCP管理中维生素补充的未来研究方向.
主要方法:
- 这篇叙述性综述综合了临床前动物和临床研究的证据.
- 它检查了维生素B3,B12和D在解决NCP中的作用.
- 讨论了作用机制,包括抗炎和神经保护作用.
主要成果:
- 维生素B3,B12和D显示出通过抑制炎症,神经炎症,线粒体功能障碍和氧化应激等机制来减轻NCP的潜力.
- 这些维生素也可能调节神经退行和感觉失调.
- 临床前和临床研究的证据支持它们的治疗效用.
结论:
- 维生素补充,特别是B3,B12和D,是NCP治疗的有希望的途径.
- 进一步的研究至关重要,以确定最佳的剂量,持续时间和适用于广泛临床使用的施用方法.
- 未来的研究应该专注于开发基于证据的协议,以将维生素治疗纳入主流的NCP管理.
相关概念视频
01:30Vitamins
2.2K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.2K
01:22Photoreceptors and Visual Pathways
8.6K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
8.6K
01:24Local Anesthetics: Differential Sensitivity of Nerve Fibers
1.3K
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
1.3K
01:25Glaucoma: Overview
1.2K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.2K
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
311
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
311
01:28Angle Closure Glaucoma: Treatment
1.1K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.1K