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基于纳米孔的生物标记检测传感:从基本原则到转化诊断

Narlawar Sagar Shrikrishna^1,2, Sonu Gandhi^3,4

¹BRIC-National Institute of Animal Biotechnology (NIAB), Hyderabad, 500032, Telangana, India.

Journal of nanobiotechnology

|October 11, 2025

概括

纳米孔传感为疾病诊断提供了敏感的,无标签的单个分子检测. 最近的进展提高了特异性,并使精准医学的便携式医疗保健监测工具成为可能.

科学领域:

生物技术是生物技术.
生物感应是一种生物感应.
分子诊断学分子诊断

背景情况:

纳米孔传感通过离子电流监测提供无标签的单分子分析.
最近的进展扩大了纳米孔应用到各种生物分子和复杂的生物样本.

研究的目的:

审查纳米孔生物传感技术最近的进展 (过去5年).
突出检测性能,特异性和临床应用方面的改进.

主要方法:

专注于识别策略,工程毛孔化学和先进的数据分析技术.
审查纳米孔制造和表面工程的发展.

主要成果:

提高各种生物标志物的检测灵敏度和特异性.
扩大了从核酸到小代谢物的分析范围.
迈向便携式诊断系统的进展.

结论:

纳米孔生物传感是一个快速发展的领域,具有早期疾病检测的巨大潜力.
发展将基础研究和临床诊断与精准医学联系起来.
未来有望提供可访问的,快速的健康监测工具.

关键词:

生物纳米孔生物纳米孔生物标志物诊断生物标志物诊断纳米孔生物传感器护理中心检测检测单个分子检测检测.固态纳米孔是一种固态纳米孔.

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