口服可降解的纳米盔甲辅助益生菌用于改造肠道微环境和治疗骨质疏松症
Zhiqiang Li1,2,3, Xueqiang Deng1,2, Chengpeng Qiu4
1Department of Rehabilitation Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, P. R. China.
Journal of nanobiotechnology
|October 11, 2025
概括
用酸和多巴胺覆盖Lactobacillus rhamnosus (LR) 益生菌会产生一种保护层 (L@Q-Ca/PDA). 这种增强的益生菌显著改善了骨质疏松症的治疗,通过提高肠道的生存率和治疗效果.
科学领域:
- 生物医学工程 生物医学工程
- 微生物学 微生物学
- 整形外科 整形外科 整形外科
背景情况:
- 改善肠道微环境和调节肠道菌群对于骨质疏松症治疗至关重要.
- 口服益生菌显示出预防骨质损失的潜力,但它们的有效性受到胃肠道低生存率的限制.
- 提高益生菌生存率和治疗效果对于骨质疏松症管理中的临床应用至关重要.
研究的目的:
- 开发一种新的策略,以提高口服益生菌对骨质疏松症的生存率和治疗疗效.
- 使用金属网络和多巴胺聚合,为Lactobacillus rhamnosus (LR) 制造一种保护性涂层.
主要方法:
- 在Lactobacillus rhamnosus (LR) 上使用素和离子形成金属网络 (L@Q-Ca).
- 在LR表面上聚合多巴胺,形成一个保护层 (L@Q-Ca/PDA).
- 评估了涂层益生菌在胃肠道和骨质疏松症模型中的生存率和治疗效果.
主要成果:
- 与未涂层益生菌相比,L@Q-Ca/PDA涂层益生菌在胃肠道中生存率显著更高.
- 涂层的益生菌对骨质疏松症有增强的治疗作用,抵消肠道炎症,氧化应激和屏障损伤.
- 被涂层的益生菌对素和短链脂肪酸的改善吸收进一步有利于骨微环境,并恢复了骨质细胞/骨质细胞平衡.
结论:
- L@Q-Ca/PDA涂层策略是一种安全,可靠和高效的方法,可以提高骨质疏松症治疗中口服益生菌的疗效.
- 这种方法有效地改善肠道微环境,减少全身炎症,促进骨健康.
- 强化益生菌具有广泛的临床应用在治疗骨质疏松症的巨大潜力.
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