耐力运动后腹部皮下脂肪组织中的分子反应:运动强度的影响
Cheehoon Ahn1,2, Tao Zhang1, Thomas Rode1
1Substrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, USA.
The Journal of physiology
|October 12, 2025
概括
急性炼会根据强度对腹部脂肪基因表达产生不同的影响. 高强度的运动会促进炎症基因,而低强度的运动会促进蛋白质合成和能量生产的途径,从而影响长期的代谢健康.
科学领域:
- 运动生理学和分子生物学.
- 脂肪组织生物学和新陈代谢.
- 转录组学和蛋白质组学.
背景情况:
- 脂肪组织的慢性炼适应对于心脏代谢健康至关重要.
- 启动这些长期适应的急性分子触发器在很大程度上仍未定义.
- 了解早期脂肪组织对运动的反应是阐明训练益处的关键.
研究的目的:
- 为了比较低,中等和高强度运动对常规炼者的腹部皮下脂肪组织 (aSAT) 转录组的急性影响.
- 为了研究运动诱导的基因表达,蛋白质酸化和循环细胞因子在不同的运动强度的变化.
- 在aSAT.中识别运动反应性基因群和细胞类型特定反应.
主要方法:
- 45名经常炼的人进行了一次低强度连续 (LOW),中等强度连续 (MOD) 或高强度间歇 (HIGH) 运动.
- 在运动前和运动后采集aSAT活检样本,用于大量RNA测序和蛋白质免疫试验.
- 进行了网络和细胞类型分析,以解释转录组数据.
主要成果:
- 高强度运动可以提高与血管生成和胰岛素信号传递相关的基因的调节.
- 适度和低强度的运动调高了参与细胞外矩阵重塑,核糖体生物发生和氧化酸化的基因.
- 运动强度调节了aSAT激活的特定转录基因通路,而时钟基因和ERK酸化反应在强度上是相似的.
结论:
- 无论强度如何,急性运动都会改变脂肪组织中的基因表达和ERK酸化.
- 运动强度显著塑造了aSAT的早期转录基因反应,并激活了不同的途径.
- 这些强度依赖的急性反应可能有助于脂肪组织对运动训练的长期结构和功能适应,影响心脏代谢健康.
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