一个新的低调全流皮心室辅助装置
Martin C Cook1, Sara Inglis2, Jordon Honeck1
1From the VenstraMedical US Inc., Minneapolis, Minnesota.
概括
这项研究引入了一种针对心脏性休克患者而设计的新型穿皮心室辅助装置 (pVAD). 新的pVAD显示出有效的心脏功率输出和低血解,提高了效率和安全性.
科学领域:
- 心血管工程 心血管工程
- 医疗器械 医疗器械
- 干预心脏病学 干预心脏病学
背景情况:
- 透皮心室辅助装置 (pVAD) 对于管理心脏性休克 (CS) 至关重要,但高不良事件率需要改进设计.
- 现有的pVAD需要对心脏功率输出 (CPO) 进行增强,以获得更好的疗效和降低配置,以最大限度地减少并发症.
研究的目的:
- 开发和评估一种新的,低调的pVAD,具有改进的CPO和独特的交付系统.
- 评估设备的 in vitro 和 in vivo 性能,重点关注流量,耐用性和对本源心脏功能的影响.
主要方法:
- 开发使用尼醇和聚合物用于低形插入的可折叠螺旋轮.
- 采用独特的9法 (9Fr) 输送系统进行跨导管植入和取回.
- 在体外头部流量测试,耐久性试验,以及在羊模型 (健康和CS) 中的急性体内研究.
主要成果:
- 在体外试验中,在80mm Hg时达到5.0 L/min,在60mm Hg时达到7.0 L/min.
- 耐用性测试显示连续运行长达20天.
- 在体内研究表明,成功的透过导管输送,取回,本地心脏支持,足够的心脏输出 (高达7L/分钟) 低血解在CS模型,和多天功能在健康模型.
结论:
- 新的pVAD在实现高CPO和支持本地心脏功能方面显示出有前途的表现.
- 低调的设计和9Fr输送系统有助于减少侵入性植入和检索.
- 需要进一步开发以解决不良事件发生率和优化CS患者的pVAD治疗.
关键词:
9Fr pVADAD 9Fr pVAD 9Fr pVAD 9Fr pVAD 9Fr pVAD 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9Fr 9r9r9r9r9r9r9r9r9r9r9r9r这是一个可折叠的pVAD.可以扩展的pVAD.全流量 pVADAD 的时间.一个直径小的pVAD.通过导管穿透皮肤的心室辅助装置.更多相关视频
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