评估神经髓炎光学谱系障碍中的睡眠障碍:定性和定量方法的比较
Sabiha Türe1, Yesim Beckmann1, Enise Nur Özlem1
1Department of Neurology, Medical Faculty of İzmir Katip Çelebi University, İzmir, Turkey.
概括
神经炎光学谱系障碍 (NMOSD) 患者表现出显著的睡眠宏观结构变化,包括更高的阻断性睡眠呼吸暂停综合征 (OSAS),高睡眠症和不安腿综合征 (RLS) 的发生率. 早期查这些睡眠障碍对于改善NMOSD患者的生活质量至关重要.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 神经免疫学 神经免疫学
背景情况:
- 神经脊髓炎光学谱系障碍 (NMOSD) 是一种罕见的自身免疫性疾病,向中枢神经系统.
- 在NMOSD患者中经常报告睡眠障碍,但往往诊断不足和治疗不足.
- 了解睡眠宏观结构的改变对于全面的NMOSD患者护理至关重要.
研究的目的:
- 为了评估睡眠宏观结构和识别睡眠障碍,如高睡眠症,呼吸暂停风险和NMOSD患者的不安腿综合征 (RLS).
- 为了将调查问卷数据与定量睡眠测试结果相关联.
- 预测需要进一步睡眠调查的NMOSD患者.
主要方法:
- 一项前性研究,涉及26名NMOSD患者和20名健康对照.
- 使用了多睡眠图 (PSG) 和多重睡眠延迟测试 (MSLT).
- 管理的问卷:匹兹堡睡眠质量指数 (PSQI),爱普沃思睡眠度量 (ESS),STOP-Bang,RLS诊断和严重程度等级,贝克抑郁 inventory (BDI).
主要成果:
- 与对照组相比,NMOSD患者的NREM1比率增加,更高的呼吸暂停-呼吸暂停指数 (AHI) 组成部分,以及较低的最低O2和度.
- 通过MSLT,通过MSLT观察到更短的睡眠延迟时间和更频繁的高睡眠症/麻醉症.
- 在NMOSD患者中观察到较高的ESS,PSQI,RLS流行率和BDI得分.
结论:
- 睡眠宏观结构在NMOSD中显著改变,阻断性睡眠呼吸暂停综合征 (OSAS),高睡眠症/麻醉症和RLS的患病率增加.
- 使用定性和定量方法早期识别睡眠障碍是必不可少的.
- 及时治疗睡眠障碍可以改善NMOSD患者的生活质量.
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