PhenoAge加速预测SARS-CoV-2疫苗接种和感染后抗体持久性和突破性感染
Jeng-How Yang1, Chia-Lin Lee2, Ya-Fang Chiu3
1Division of Infectious Diseases, Department of Internal Medicine, New Taipei Municipal TuCheng Hospital, Taiwan; College of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan County 333, Taiwan.
Journal of infection and public health
|October 12, 2025
概括
自然感染和复发疫苗显著增强了抗SARS-CoV-2抗体. 加快的生物衰老增加了感染风险,突出了除了疫苗剂量之外需要足够的抗体水平,以防止突破COVID-19.
科学领域:
- 免疫学 免疫学 免疫学
- 老年学是指老年学的学科.
- 传染病流行病学 传染病流行病学
背景情况:
- 对SARS-CoV-2的抗体耐用性在接种疫苗或感染后有所不同.
- 生物衰老对这些抗体反应的影响尚不清楚.
研究的目的:
- 研究PhenoAge加速对抗SARS-CoV-2抗体水平的影响.
- 评估PhenoAge加速和突破SARS-CoV-2感染风险之间的关系.
主要方法:
- 分析了针对SARS-CoV-2受体结合域的血清抗体度.
- 使用9个临床生物标志物计算了PhenOAge和PhenOAge加速.
- 从93名参与者收集数据,每3个月进行一次随访.
主要成果:
- 自然感染是高抗体水平的最强预测因素 (OR: 124.79),其次是≥3个疫苗剂量 (OR: 4.36).
- 抗体标位>2500 IU/mL与对突破性感染的保护相关 (HR:0.04).
- 老化加速与感染风险增加有关 (HR:4.75).
结论:
- 补充疫苗接种和自然感染对于维持高抗体标位至关重要.
- 加快的生物衰老可能会增加SARS-CoV-2感染的风险.
- 足够的抗体水平,而不仅仅是疫苗剂量,对于预防突破性感染至关重要.
相关概念视频
01:51Vaccinations
51.2K
Overview
51.2K
01:23Immunological Memory
15.0K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
15.0K
01:31Active versus Passive Immunity
10.0K
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
Active Immunity
Active immunity refers to the resistance one develops...
10.0K
00:42Cross-reactivity
32.8K
Overview
32.8K
01:23Cells of the Adaptive Immune Response
8.5K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.5K
01:22Development of Immunocompetence
789
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
789