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疏水性天然深度浸泡溶剂作为固体吸附剂中对的绿色脱吸介质:一项概念验证研究

Emilia C Abraham¹, Sabrina B Mammana², Marcela A Michaut¹

¹Laboratorio de Biología Reproductiva y Molecular, Instituto de Histología y Embriología de Mendoza (IHEM), Universidad Nacional de Cuyo-CONICET, Argentina; Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo, Argentina.

Journal of chromatography. A

|October 12, 2025

概括

开发了一种新的,环保的方法,使用疏水性天然深度溶解剂 (H-NADES) 来分析尿液中的. 这种可持续的方法减少了溶剂使用和环境影响,同时保持了生物监测的高分析性能.

科学领域:

环境化学环境化学
分析化学分析化学
绿色化学绿色化学

背景情况:

烯是人类尿液中常见的内分泌干扰物,需要可靠的生物监测方法.
传统的固体相提取 (SPE) 方法通常依赖于大量的有机溶剂,造成环境问题.
需要可持续和高效的样品制备技术来分析复杂的生物矩阵中的 parabens.

研究的目的:

开发和优化一种可持续的样本制备方法,用于量化人类尿液中的四种类型.
评估使用疏水性天然深层水溶剂 (H-NADES) 作为SPE中传统有机溶剂的绿色替代品.
评估开发的基于H-NADES的方法的分析性能和环境影响.

主要方法:

最初的方法开发涉及选C18,PSA和Florisil Sorbents与甲醇:水化.
最优化的方法使用了一种疏水性天然深度浸泡溶剂 (H-NADES) 与超声波辅助脱吸.
采用了Box-Behnken设计,以优化H-NADES的体积,超声波时间,温度和缓冲体积.

主要成果:

通过H-NADES方法,使用减少的溶剂体积和更短的提取时间,实现了对 parabens 的优异回收.
该方法表现出良好的线性 (0.017-50μg mL-1),精度 (RSD<10%),以及低的检测极限 (0.006-0.022μg mL-1).
绿色化学指标 (AGREE,AGREEprep,ChlorTOX) 证实了H-NADES程序的环保性质.

结论:

疏水性天然深度浸泡溶剂 (H-NADES) 为从尿液中提取烯的有机溶剂提供了可行和可持续的替代品.
开发的H-NADES方法提供了一种简单,环保,高性能的方法,用于对 parabens 的常规生物监测.
这项研究强调了H-NADES在复杂生物样本的绿化分析方法方面的潜力.

关键词:

绿色样品的准备绿色样品的准备天然的深层环氧溶剂 (NADES)帕拉本类药物可以超声波辅助脱吸方式尿液分析尿液分析

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