西格玛-1受体激活可以通过减轻内分泌网膜应激和神经炎症来改善与年龄相关的术后认知功能障碍
1Department of Anesthesiology, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi, China.
降低的Sigma-1受体 (Sigma-1R) 水平有助于与年龄相关的术后认知功能障碍 (POCD). 西格玛-1R激动剂PRE-084通过减少神经元应激和炎症,改善了老年小鼠的认知功能.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 手术后认知障碍 (POCD) 显著影响老年人,导致认知能力下降.
- 西格玛-1受体 (Sigma-1R) 是一种神经保护性蛋白质,与细胞应激反应有关.
- 在Sigma-1R中与年龄相关的变化可能会影响POCD的易感性.
研究的目的:
- 调查Sigma-1R在年龄依赖的POCD易感性中的作用.
- 评估西格玛-1R激动剂PRE-084在POCD老年小鼠中的治疗潜力.
主要方法:
- 利用一个探索性腹腔切除术小鼠模型来诱导POCD.
- 评估了依赖年龄的海马体Sigma-1R表达和定位.
- 在手术后使用PRE-084并评估认知功能和分子标记.
主要成果:
- 与成年小鼠相比,老年小鼠的基底海马体Sigma-1R水平较低,手术后的升调水平较低.
- 在老年小鼠中,PRE-084的使用显著改善了认知功能.
- PRE-084治疗减轻了内分泌网膜压力,神经炎症和调节了NF-κB和CREB通路.
结论:
- 对手术压力的差异性Sigma-1R反应对与年龄相关的POCD病变发生至关重要.
- 通过通过Sigma-1R激活提供神经保护,PRE-084显示POCD的治疗承诺.
- 准Sigma-1R可能为预防或治疗POCD提供一种新的策略.
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