在自闭症谱系障碍和强迫症障碍中,功能和结构的明显和相似的多模式大脑变化
Zixuan Guo1, Ruoyi Chen2, Shu Xiao2
1Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, 510630, China; Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, 510630, China; Department of Medical Imaging, Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, China.
Journal of psychiatric research
|October 12, 2025
概括
这一元分析揭示了自闭症谱系障碍 (ASD) 和强迫症障碍 (OCD) 中不同的和共享的大脑变化. 这两种情况都显示出与神经递质系统相关的功能和结构变化.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 自闭症谱系障碍 (ASD) 和强迫症 (OCD) 经常与静止状态的功能和结构性大脑变化有关.
- 需要进行全面的元分析,以巩固这些条件中的共同和独特的神经生物学变化.
研究的目的:
- 与神经类型对照组 (NCs) 相比,对ASD和强迫症患者的静止状态区域同质性 (ReHo) 和灰质体积 (GMV) 变化进行全脑元分析.
- 为了识别ASD和强迫症之间的融合和分离的功能和结构性大脑变化.
- 探索这些变化的关联与关键的神经递质系统.
主要方法:
- 一个系统的分析发表的研究检查ReHo和GMV在ASD和强迫症.
- 包括17项针对ASD和18项针对强迫症的ReHo研究;52项针对ASDGMV和62项针对强迫症GMV的研究.
- 全脑分析以确定区域性变化和重叠的发现.
主要成果:
- 自闭症显示左侧胰岛和下额 (IFG) 的ReHo降低.
- 强迫症在左侧IFG,胰岛和前带带皮层/中部前额皮层 (ACC/mPFC) 显示了增加的ReHo.
- 自闭症在左小脑表现出减少的GMV;强迫症在双边IFG,insula和ACC/mPFC表现出减少的GMV.
- 收的ReHo变化被观察到在左侧IFG和insula对于ASD和OCD.
- 在这两种疾病中,功能和结构的变化都与血清激素,多巴胺激素,GABA激素和谷氨酸激素系统有空间联系.
结论:
- 该元分析确定了ASD和强迫症中功能和结构性大脑变化的独特和重叠的模式.
- 在ASD和强迫症中,这些神经生物学变化与主要的神经递质系统有关.
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