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探索使用fNIRS使用iTBS后皮质可塑性的年龄和半球差异.

Amy Miller1, Richard Allen1, Rumana Chowdhury2

  • 1School of Psychology, Faculty of Medicine and Health, University of Leeds, LS2 9JT, UK.

Neuroscience
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PubMed
概括

对前额叶皮层进行的非侵入性脑刺激 (iTBS) 对不同年龄组的脑氧化有不同的影响. 年轻的成年人表现出增加的活动,而老年人表现出活动减少,突出了年龄相关的大脑刺激效应.

关键词:
年龄化 衰老 衰老认知能力 认知能力 认知能力背侧前额皮质 (DLPFC) 是一个前额皮质.功能性近红外光谱学 (fNIRS) 是一种功能性近红外光谱学.通过的磁性刺激 (TMS)

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科学领域:

  • 神经科学是一个神经科学.
  • 认知科学 认知科学
  • 老年学是指老年学的学科.

背景情况:

  • 前额叶皮质 (PFC) 的非侵入性脑刺激可以改善老年人的认知功能.
  • 刺激左侧与右侧脊侧前额叶皮层 (DLPFC) 对大脑氧化的具体影响以及这些影响如何随年龄而变化,尚不清楚.

研究的目的:

  • 调查左侧和右侧DLPFC刺激对前额氧化水平的影响差异.
  • 检查这些影响是如何在不同年龄组 (年轻人,中年人和老年人) 中调节的.

主要方法:

  • 45名成年人在受试者内部设计中接受了左侧和右侧DLPFC (F3和F4) 的间歇性甲基突发刺激 (iTBS).
  • 功能近红外谱学 (fNIRS) 在刺激前后的四个认知任务中测量了前额氧化 (HbO) 变化.
  • 来自12个频道的fNIRS数据涵盖了左侧,中侧和右侧PFC.

主要成果:

  • 观察到DLPFC iTBS对大脑氧化反应的年龄相关差异.
  • 年轻的成年人在抑制任务期间,左 iTBS 显示HbO 增加.
  • 中年成人在学习任务中表现出双边HbO增加与右 iTBS,而老年人显示下降.
  • 老年人表现出刺激后HbO降低,特别是在右 iTBS后的中线区域和左 iTBS后的双边区域.

结论:

  • 作为DLPFC iTBS的反应,氧化变化的分散性取决于年龄.
  • 年轻的成年人显示大脑活动的"上调",表明效率增加,而老年人显示"下调".