过多的能量摄入因果性地增加了血压和高血压的风险:一个两个样本的门德尔随机化分析分析
Farshad Teymoori1, Mahdi Akbarzadeh2, Niloufar Saber3
1Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran; Nutrition and Endocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clinical nutrition ESPEN
|October 12, 2025
概括
过多的能量摄入与高血压 (BP) 和高血压 (HTN) 有因果关系. 这项门德尔随机化研究证实了直接的关系,强调了能量平衡对心血管健康的重要性.
科学领域:
- 心血管遗传学 心血管遗传学
- 营养流行病学 营养流行病学
- 公共卫生 公共卫生
背景情况:
- 过量的能量摄入对血压 (BP) 和高血压 (HTN) 的影响需要进一步研究.
- 现有的研究尚未广泛探索饮食能量消耗和高血压之间的因果关系.
- 门德尔随机化 (MR) 提供了一个强大的方法,可以从观测数据中推断因果关系.
研究的目的:
- 评估能量摄入量与静缩血压 (SBP),静缩血压 (DBP) 和高血压 (HTN) 之间的因果关系.
- 使用孟德尔的随机化 (MR) 方法来评估这种因果关系.
- 利用大规模的全基因组关联研究 (GWAS) 进行强大的遗传分析.
主要方法:
- 使用来自欧洲祖先的大规模GWAS数据集的总结统计数据进行了MR分析.
- 采用多种MR方法,包括反变量加权 (IVW),加权中位数和MR-Egger回归.
- 使用了来自英国生物银行的GWAS能量摄入 (N = 64,979) 和BP/HTN (N > 361,000) 数据.
主要成果:
- 每一个标准偏差 (SD) 增加的能量摄入量都与每一个SD的SBP (β = 0.093) 和DBP (β = 0.070) 的显著增加有关.
- 观察到能量摄入量和高血压之间的因果关系 (OR = 1.004).
- 在各种MR方法中,研究结果一致,没有证据表明存在显著的偏差或异质性.
结论:
- 这项研究提供了强有力的证据,支持过多的能量摄入量和高血压之间的直接因果关系.
- 结果表明,增加能源消耗是导致高血压发展的一个因素.
- 这些发现强调了管理能量平衡对心血管健康和高血压预防的重要性.
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