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Updated: Jan 15, 2026

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提亚基松对登革热病毒的合成和抗病毒活性

Mohd Usman Mohd Siddique1, Deepak Shilkar2, Vasavi Garisetti3

  • 1Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi 835215, JH, India; Department of Pharmaceutical Chemistry, Shri Vile Parle Kalevani Mandal's Institute of Pharmacy, Dhule 424001, MH, India.

Bioorganic & medicinal chemistry letters
|October 12, 2025
PubMed
概括

研究人员开发了一种强大的抗病毒化合物,3c,针对登革热病毒 (DENV),与原始化合物3a相比,有效性和选择性显著提高. 需要进一步的研究来优化其交付.

关键词:
抗病毒活性具有抗病毒活性.登革热是因为登革热.在体外的ADME ADME.在体内PK研究PK研究.分子动力学分子动力学铁亚类 (Thiazoles) 是一种有机物.

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Nitrous acid, a weak acid, is prepared in situ via the reaction of sodium nitrite with a strong acid under cold conditions. This nitrous acid prepared in situ reacts with primary arylamines to form arenediazonium salts. Such reactions are known as diazotization reactions. As shown in Figure 1, the formation of arenediazonium salts begins with the decomposition of nitrous acid in an acidic solution to give nitrosonium ions.
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The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the para...
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