在情绪障碍中与运动相关的神经振荡
Yi Xia1, Xiaoqin Wang1, Shujia Hu1
1Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China.
NeuroImage
|October 12, 2025
概括
与主要抑郁症 (MDD) 患者相比,双极性障碍 (BD) 患者的运动技能较差,神经振荡有明显的变化. 这些发现突出了情绪障碍之间运动障碍的特定神经生理差异.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 计算神经科学是一种神经科学.
背景情况:
- 运动症状在情绪障碍中很普遍,影响治疗反应和预后.
- 情绪障碍中运动功能障碍的潜在神经机制尚不清楚.
- 电机电路内的和β波段的神经振荡对于运动控制至关重要.
研究的目的:
- 调查双相情感障碍 (BD) 和主要抑郁障碍 (MDD) 患者的运动功能和相关的神经振荡.
- 为了比较BD,MDD和对照组之间运动控制中的神经生理变化.
- 探索BD和MDD患者之间神经振荡模式的潜在差异.
主要方法:
- 144名BD患者,136名MDD患者和125名对照患者在Go/No-Go任务期间接受了磁脑扫描 (MEG).
- 摩托性能使用Trail Making Test A和B进行了评估.
- 分析包括试验间相连贯性,与事件相关的光谱扰动,相锁定值和补充运动区域 (SMA) 和初级运动皮层 (M1) 的相振幅合 (PAC).
主要成果:
- 双极性障碍患者的运动性能明显低于严重抑郁症患者.
- 患有BD的患者表现出与beta事件相关的同步和试验间相合的减少,以及与beta事件相关的脱同步的增加.
- 患有MDD的患者在SMA中表现出theta-beta阶段-振幅合的减少,表明明显的振荡功能障碍.
结论:
- 神经振荡和连接的明显神经生理变化与BD和MDD的运动障碍有关.
- 这些发现强调了情绪障碍病理生理学振荡变化的复杂性和特异性.
- 对神经振荡的进一步研究可能有助于预测临床结果,并开发针对情绪障碍的有针对性的干预措施.
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