爆发的Burkholderia cepacia复杂感染与本质上受污染的商业0.5%的赫西丁溶液相关
T Dilokkunanant1, K Malathum2, D Chotiprasitsakul2
1Infection Prevention and Control Service, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
The Journal of hospital infection
|October 12, 2025
概括
与受污染的赫西丁葡萄糖酸盐 (CHG) 溶液相关的Burkholderia cepacia复合体 (BCC) 爆发影响了三个手术后的患者. 迅速干预和产品撤销成功控制了医院获得的感染.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 在医疗机构中,Burkholderia cepacia复合体 (BCC) 感染是令人担忧的.
- 在2024年5月进行前轨道推进 (FOA) 手术后出现了两例BCC感染病例.
- 这促使对潜在来源和控制措施进行调查.
研究的目的:
- 确定BCC感染的来源.
- 实施干预措施来控制正在进行的感染.
- 制定措施以防止未来的事件发生.
主要方法:
- 案例定义:实验室确认的BCC分离物 (2023年12月至2024年5月).
- 审查了医疗记录,采访了工作人员,并评估了感染控制合规性.
- 收集环境样本进行微生物学分析,并进行多位置序列类型化 (MLST).
主要成果:
- 鉴定了三种BCC感染,与0.5%的水性素酸盐 (CHG) 溶液有关.
- 在涉及的CHG溶液的10个样本中检测到BCC.
- MLST证实所有临床和环境隔离物都是Burkholderia cenocepacia,表明这是一个共同源爆发.
结论:
- 多学科团队对医院感染的监测对疫情控制至关重要.
- 污染产品的撤回和工作人员的再教育解决了疫情.
- 需要更严格的法规来防止制造过程中消毒剂的污染.
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