胰岛素敏感性,遗传倾向和心房的风险:一个前性队列研究
Yutong Wang1, Yanwen Chen1, Xinyang Song2
1Cardiology department, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
较高的估计葡萄糖处置率 (eGDR),衡量胰岛素敏感性,显著降低心房动 (AF) 的风险,即使在具有高遗传倾向的个体中.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 遗传学 遗传学 是一个
背景情况:
- 估计的葡萄糖排放率 (eGDR) 是胰岛素敏感性和心血管健康的临床指标.
- 关于eGDR和遗传倾向对心房动 (AF) 风险的综合影响尚不清楚.
研究的目的:
- 为了研究eGDR与发生性AF风险之间的纵向关联.
- 评估eGDR和遗传倾向对AF发展的联合和相互作用影响.
主要方法:
- 利用了来自431,572名参与者的英国生物库数据.
- 使用腰围,高血压和糖化血红蛋白计算的eGDR.
- 评估的遗传倾向与AF多基因风险评分 (PRS).
- 采用卡普兰-梅尔曲线,受限立方斜线模型和考克斯回归分析.
主要成果:
- 较高的eGDR四分位数与显著较低的AF发病率相关 (日志等级P <.001).
- 在eGDR和AF风险之间观察到非线性,L形的关联 (P非线性<.001).
- 在eGDR中每增加一个单位,AF风险降低了9% (HR 0.91;P <.001).
- 与高PRS和低eGDR (HR 0.26;P <.001) 相比,低PRS和高eGDR的个体的AF风险降低了74%.
结论:
- 在所有遗传风险水平上,eGDR对AF具有剂量依赖的保护作用.
- 胰岛素抵抗成为AF预防的潜在治疗点.
- 改善的胰岛素敏感性提供了对AF的保护,无论遗传风险如何.
更多相关视频
28:13Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
08:10Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
相关概念视频
Coronary Artery Disease I: Introduction
Diabetes Mellitus: Type 2 and Gestational
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
