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巴灵顿核:一个庞丁排便大脑区域,表现出迅速和延迟的排便反应

Kota Bussaka¹, Yoshimasa Tanaka¹, Kunio Kondoh²

¹Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Cellular and molecular gastroenterology and hepatology

|October 12, 2025

概括

研究人员确定了大脑的大脑.

科学领域:

神经科学是一个神经科学.
胃肠病学胃肠病学
身体生理学身体生理学

背景情况:

慢性便秘会对生活质量产生负面影响.
排便依赖于由中枢神经系统协调的直肠运动.
大脑对排便的调节仍然在很大程度上是未知的.

研究的目的:

确定控制排便的大脑区域 (排便大脑区域 - DBA).
研究特定神经元群体在排便控制中的作用.
阐明调节远端结肠运动的神经通路.

主要方法:

利用伪狂犬病病毒 (PRV) 进行跨突触追踪以识别DBA.
采用光遗传和化学遗传技术来操纵神经元活动.
在排便期间进行体内神经活动监测.

主要成果:

确定了巴林顿核 (Bar),角位 (LC),腹侧周水管灰色 (vlPAG) 和副腹下垂体核 (PVH) 作为关键的DBA.
巴尔和LC中的膀性谷氨酸转运体2 (VGluT2) 神经元和巴尔中的皮质otropin释放激素 (CRH) 神经元分别介导着快速和延迟的结肠收缩.
PVH^VGluT2和vlPAG^CRH神经元在Bar^VGluT2神经元上游起作用,影响排便.

结论:

巴林顿核 (巴尔) 作为庞丁排便大脑区域 (DBA) 的功能.
巴尔^VGluT2和巴尔^CRH神经元不同调节迅速和延迟的排便.
PVH^VGluT2和vlPAG^CRH神经元是通过Bar^VGluT2通路进行排便的上游调节者.

关键词:

慢性便秘慢性便秘排泄是排泄的过程.排便大脑区域排便大脑区域

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