下尿道症状与帕金森病患者的运动和认知功能的相关性
Nikan Golesorkhi1, Valentina Leta2, Kallol Ray Chaudhuri2,3
1Faculty of Life Sciences and Medicine, Guy's Campus, King's College London, London, UK.
International neurourology journal
|October 13, 2025
概括
在帕金森病 (PD) 中,尿失禁的严重程度与认知衰退比运动症状更相关. 在为PD患者规划泌尿干预时,认知功能至关重要.
科学领域:
- 神经学 神经学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 老年病的医生 老年病的医生
背景情况:
- 帕金森病 (PD) 是一种进展性神经退行性疾病,影响60岁以上的人群中约1%的人.
- 下尿路症状 (LUTS) 影响高达85%的PD患者,显著降低生活质量 (QoL).
- 有限的研究探讨了蒙特利尔认知评估 (MoCA) 的认知功能,运动症状和PD中的LUTS之间的关系.
研究的目的:
- 研究帕金森病患者的认知表现 (MoCA分数) 与运动症状和LUTS严重程度之间的关联.
- 评估LUTS对PD患者的QoL的影响.
- 为了比较药物原始和非药物原始的PD患者之间的认知和临床特征.
主要方法:
- 观察性,横截面研究,涉及PD患者在运动障碍专家诊所.
- 采用验证问卷进行前性收集的数据:ICIQ-MLUTS,ICIQ-FLUTS,统一的PD评分表 (运动检查),修改的Hoehn和Yahr以及MoCA.
- 使用Stata/MP 17.进行的统计分析.
主要成果:
- 分析了18名PD患者 (平均年龄69岁,中位数疾病持续时间为4年).
- 尿失禁的严重程度与较差的QoL (r=0.76) 和LUTS (r=0.82) 强烈相关,但与MoCA分数 (r=-0.52,P=0.046) 有负相关.
- 尿失禁和运动症状严重程度之间没有发现相关性 (r=0.09). 没有使用过药物的患者表现出更高的运动和LUTS分数.
结论:
- 在PD中,认知障碍与尿失禁的严重程度比运动缺陷更密切相关.
- 在评估PD患者泌尿器科干预措施时,应考虑认知功能与运动功能一起.
- 这项研究强调了帕金森病的神经,泌尿和认知方面的复杂相互作用.
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