相关实验视频

Updated: Aug 8, 2026

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

在过度活跃的膀患者中改变了周周导管灰色功能连接:使用集群分析进行休息状态功能磁共振成像研究

Susana Fernández Chadily¹, Naomi R van Houtum¹, Marianne E van Klaveren¹

¹Department of Urology, Mental Health and Neuroscience Research Institute, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands.

International neurourology journal

|October 13, 2025

概括

过度活跃的膀患者在周水道灰色 (PAG) 中显示出静态的大脑膀信号,与健康个体不同. 这种缺乏动态的PAG重组可能会导致过度活性膀 (OAB) 病理生理学.

科学领域:

神经科学是一个神经科学.
泌尿器科泌尿器科泌尿器科泌尿器科
医疗成像医学成像

背景情况:

过度活性膀 (OAB) 综合征显著影响生活质量,病理生理学不明.
大脑 - 膀神经网络的破坏,特别是水道灰色 (PAG),与OAB有关.
在脑膀轴内,PAG对于双向通信至关重要.

研究的目的:

研究PAG的基于功能连接的组织在时间上的动态变化.
为了比较OAB患者和健康对照 (HC) 之间的PAG组织.

主要方法:

在7特斯拉使用休息状态功能磁共振成像 (fMRI).
参与者包括OAB患者和空膀HC患者.
基于功能连接的集群分析评估了时间依赖的PAG组织.

主要成果:

在时间依赖的PAG功能组织中观察到显著的群体差异 (P=0.017).
健康的对照组在扫描过程中表现出PAG细分的动态重组.
OAB患者在很大程度上表现出静态的PAG功能组织,时间变化最小.

结论:

研究结果表明,OAB患者的PAG信号和感官处理发生了变化.
缺乏动态PAG重组可能是导致OAB病理生理学的因素.
这项研究为OAB背后的神经机制提供了新的见解.

关键词:

大脑绘制地图.功能性磁共振成像技术功能性磁共振成像技术过度活动的膀.周边水道灰色周边水道灰色

更多相关视频

Cystometric and External Urethral Sphincter Measurements in Awake Rats with Implanted Catheter and Electrodes Allowing for Repeated Measurements

Cystometric and External Urethral Sphincter Measurements in Awake Rats with Implanted Catheter and Electrodes Allowing for Repeated Measurements

Published on: January 30, 2018

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

相关概念视频

Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...