儿科患者的真菌感染:治疗中的挑战和考虑
Elio Castagnola1, Marcelo Mariani1, Erica Ricci1
1Department of Medical-Pediatric Sciences, Infectious Diseases Unit IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Expert review of anti-infective therapy
|October 13, 2025
概括
儿童的侵袭性真菌病 (IFD) 难以诊断和治疗. 本次审查强调了改善儿科特定研究,诊断工具和标准化治疗方案的必要性,以获得更好的结果.
科学领域:
- 儿童传染病 儿童传染病
- 菌类学 菌类学是指菌类学.
- 临床药理学 临床药理学
背景情况:
- 侵袭性真菌病 (IFDs) 对儿童构成重大风险,这些风险来自于早产和遗传条件等独特因素,以及化学疗法和重症监护等成人共同风险.
- 儿科IFD诊断因样本采集,抗原检测性能变化和非特异性成像方面的挑战而复杂化.
- 儿科IFD的治疗是复杂的,因为依赖于年龄的药理动力学,有限的儿科配方和需要治疗药物监测的药物相互作用.
研究的目的:
- 为儿童患者提供IFD流行病学,诊断和治疗的叙述性综述.
- 突出IFD在儿童中管理的挑战和复杂性.
- 强调需要改善儿科专用策略的必要性.
主要方法:
- 关于儿科侵入性真菌病的现有文献的叙述性综述.
- 综合有关流行病学因素,诊断方式和治疗方法的信息.
- 分析特定于儿科人口的诊断和治疗方面的挑战.
主要成果:
- 国际儿童基金会对儿童发病率和死亡率做出重大贡献.
- 诊断方面的困难包括获得足够的样本,当前抗原测试的局限性和非特异性成像.
- 治疗挑战包括药物动力学,药物可用性,药物相互作用以及治疗药物监测的必要性.
结论:
- 对儿童抗真菌药物的治疗药物监测是必不可少的,而且可能会增加.
- 优先考虑儿科特定的研究和标准化治疗方案至关重要.
- 需要进行监管改革,以加快获得儿科IFD新型诊断和治疗策略.
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