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Updated: Jan 15, 2026

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奥拉巴里布新陈代谢:量子化学,对接和基于动力学的洞察力,对机制和反应性的洞察力

Anila Nuthi1, Upadhyayula Suryanarayana Murty1, Vaibhav A Dixit1

  • 1Department of Medicinal Chemistry, Department of Pharmaceuticals, Ministry of Chemicals & Fertilizers, National Institute of Pharmaceutical Education and Research, Guwahati, (NIPER Guwahati) Govt. of India, Sila Katamur (Halugurisuk), Changsari, Kamrup, 781101 Guwahati, Assam, India.

Chemical research in toxicology
|October 13, 2025
PubMed
概括

通过CYP450 3A4/5的Olaparib代谢产生有毒的代谢产物. 计算研究表明,由M6形成的反应性M12代谢物具有高度的电友性,这解释了olaparib的存在.

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