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在Aronia melanocarpa中,氨酸通过增强光受体细胞功能和抗炎作用来减轻因光引起的视网膜损伤
Mingjun Ye1,2, Long Zuo1, Xusheng Li1
1The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Department of Food Science and Engineering, Institute of Food Safety and Nutrition, Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection, Jinan University, 601 Huangpu Rd, Guangzhou, 510632, PR China. baiweibin@163.com.
Food & function
|October 13, 2025
概括
阿罗尼亚梅拉诺卡帕 (Aronia melanocarpa) 的抗氧化素 (AMA) 通过减少炎症和氧化应激来保护视网膜免受光线引起的损伤. 这项研究表明,AMA支持视觉功能和光受体健康,这表明饮食干预的潜力.
科学领域:
- 眼科医生 眼科 眼科
- 营养科学 营养科学
- 分子生物学分子生物学
背景情况:
- 过度暴露于光线会通过氧化应激和炎症引起视网膜光损伤.
- 阿罗尼亚梅拉诺卡帕 (Aronia melanocarpa) 的酸 (AMA) 显示出对视网膜保护的承诺,但机制尚不清楚.
研究的目的:
- 研究AMA对大鼠光感应视网膜损伤 (LD) 的预防作用.
- 阐明AMA对LD的潜在保护机制.
主要方法:
- 通过强烈的光照,建立了一种大鼠LD模型.
- 使用AMA进行管理并使用电网膜学 (ERG) 评估视网膜功能.
- 分析了视网膜结构,基因/蛋白质表达 (RHO,SAG,TNF-α) 和亡.
主要成果:
- AMA缓解了ERG振幅减小和外核层缩.
- 亚马增加了Rhodopsin (RHO) 和rod-arrestin (SAG) 的表达,同时降低了TNF-α的调节.
- AMA激活了Nrf2/Sirt3/SOD2通路,减少了光受体的亡,而氨-3-O-氨酸酸显示与RHO/SAG结合.
结论:
- 通过减少炎症,氧化应激和亡,AMA提供了对LD的显著光保护.
- AMA促进RHO和SAG的再生,可能是通过氨-3-O-阿拉比诺酸相互作用.
- AMA显示出作为预防或管理视网膜疾病的食补充剂的潜力.
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