针对急性喘息和喘恶化的抗生素:EAACI的立场文件和系统审查
Anne-Lotte Redel1,2, Wojciech Feleszko3, Marina Atanaskovic-Markovic4
1Department of Pulmonology, Franciscus Gasthuis & Vlietland, Rotterdam, the Netherlands.
Allergy
|October 13, 2025
概括
抗生素很少对急性喘恶化 (AAE) 有益,有限的证据表明,类药物可能会缩短学龄前儿童的AAE持续时间. 对其他年龄组需要进一步的研究.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 临床药理学 临床药理学
背景情况:
- 抗生素通常用于学前喘息和急性喘恶化 (AAE),尽管不是标准治疗.
- 这种做法仍然存在,尽管缺乏强有力的证据支持抗生素在AAE中的有效性.
研究的目的:
- 系统地审查有关抗生素在治疗AAE中的临床作用的文献.
- 为AAE管理中使用抗生素提供基于证据的建议.
主要方法:
- 在主要数据库 (Medline ALL,Embase,Web of Science,Cochrane) 进行了系统的文献搜索.
- 包括的研究是随机对照试验和队列研究,比较抗生素与安慰剂或AAE标准护理.
- 主要结局包括AAE持续时间和住院时间;次要结局包括严重程度,复发,螺旋计,成本和不良事件.
主要成果:
- 包含了15项研究,揭示了抗生素在AAE治疗中的益处的稀缺证据.
- 麦克罗利德显示有可能缩短儿童的AAE持续时间,但对于成年人缺乏数据.
- 回顾性研究将抗生素与更长的住院时间联系起来,这一发现没有随机试验支持. 益卡尔西托尼导向治疗减少了抗生素的使用,没有负面的结果.
结论:
- 有限的证据表明,类物质可能会减少学龄前喘患者的AAE持续时间.
- 没有明确的证据支持抗生素对其他年龄组的AAE的有益作用.
- 益卡尔托尼导向治疗提供了一种安全减少抗生素处方的方法.
更多相关视频
02:34Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms
Published on: May 10, 2024
1.8K
03:25Author Spotlight: Exploring Non-Pharmacological Therapies for Chronic Respiratory Diseases — Linking Intestinal Microbiome Insights to COPD Treatment
Published on: December 27, 2024
1.5K
相关概念视频
01:17Drugs Used in Lower Respiratory Disorders: Overview
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
01:29Asthma-I: Introduction
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
01:30Asthma-IV: Diagnostic and Management
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
01:28Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
01:13Asthma III: Clinical Manifestations
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...