大麻使用和心律失常风险:来自大型回顾性多中心分析的见解
Juan Vargas1, Keerthana Jyotheeswara Pillai2, Christian Tocquica-Gahona3
1Northern Arizona Healthcare, Cottonwood, Arizona, USA.
Journal of cardiovascular electrophysiology
|October 13, 2025
概括
大麻使用显著增加了患多重心律失常的风险,包括心房动和心室心律失常. 这凸显了与大麻消费相关的潜在心血管风险.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 全球大麻使用量正在上升,需要了解其对心血管的影响.
- 尽管大麻的合法化和公共卫生相关性越来越大,但大麻的节律失调潜力仍然不清楚.
研究的目的:
- 评估大麻使用与患各种心律失常的风险之间的关联.
- 评估大麻消费对心律的实际临床影响.
主要方法:
- 使用68个美国医疗保健组织的非身份电子健康记录进行了回顾性队列研究.
- 210,817名成年大麻使用者与210,817名布洛芬使用者的倾向性得分匹配.
- 使用考克斯模型和卡普兰-梅尔分析,对心房动/动,心跳动,心跳过早和心室心跳动/动的事件诊断的分析.
主要成果:
- 与使用布洛芬相比,大麻使用显著增加了所有评估的心律失常的风险.
- 对于心房动/动 (HR=1.549),心跳动 (HR=1.791) 和早跳 (HR=1.739) 观察到更高的发病率.
- 在大麻使用者中,最显著的风险增加是室腔心动减速/心肌 (HR=3.078) .
结论:
- 大麻使用与患多重心律失常的风险更高,包括与心房和心室心律失常的显著关联.
- 这些发现强调了需要进一步研究大麻对心血管的影响.
- 强调咨询患者关于大麻使用潜在的心律失常风险的重要性.
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