在生命早期进行干预以调节炎性肠病风险:影响可能是什么?
Francisco Ribeiro-Mourão1,2, Manasi Agrawal3,4,5, Joana Torres3,6,7,8
1Unidade de Gastroenterologia Pediátrica, Serviço de Pediatria, Centro Materno-Infantil do Norte Albino Aroso, Unidade Local de Saúde de Santo António, Porto, Portugal.
预防儿科炎症性肠病 (IBD) 侧重于生命早期. 策略针对母亲健康,出生因素和婴儿营养,以减轻IBD风险,尽管验证有限.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 免疫学 免疫学 免疫学
- 微生物组研究的研究.
背景情况:
- 儿科发病性炎症性肠病 (IBD) 的发病率不断上升.
- 早期暴露 (产前,产周,童年) 与IBD风险有关.
- 机制包括微生物组,免疫,表观遗传和代谢编程.
研究的目的:
- 审查潜在的IBD预防早期干预策略.
- 概述在孕产妇,分娩和产后阶段的方法.
- 为家庭提供指导,并讨论整合策略.
主要方法:
- 对观察证据和拟议机制的文献综述.
- 识别跨发展窗口的干预点.
- 综合当前的知识和新兴的研究领域.
主要成果:
- 确定了关键的干预阶段:母亲的营养/微生物组,出生方式,母乳养,产后饮食,抗生素使用,环境暴露.
- 为高风险群体 (例如,IBD父母的孩子) 突出相关性.
- 指出大多数策略都是假设的,具有有限的验证.
结论:
- 针对多种因素的早期干预措施对儿科IBD预防有希望.
- 建议的战略需要进一步的研究和验证.
- 为了成功实现整合,必须解决道德和实施方面的挑战.
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